Ingredients in Infla-mood have been shown to or may:

• Enhance healthy mood balance.¹
• Help nervous system function by assisting metabolism and synthesis of some neurotransmitters.²
• Improvements in mood after six weeks’ treatment.¹

Clinical Benefits

• Extensively clinically trialled ingredients shown to be as effective as, and able to be used alongside, pharmaceutical SSRIs without negative effects.^3,4,5,6
• Two clinical trials on BCM-95^TM turmeric and four on saffron show these ingredients, at doses found in Infla-mood, to be as effective as pharmaceuticals in supporting healthy mood. In a randomised, double-blind, placebo-controlled trial 60 patients with low mood were treated with 25.0 g BCM-95^TM turmeric per day or a pharmaceutical selective serotonin reuptake inhibitor (SSRI) for six weeks. BCM-95^TM turmeric was found to be as effective as the SSRI for supporting healthy mood.³ Similarly, in a randomised, double-blind, placebo-controlled study of 30 patients with low mood, 90 mg saffron per day was shown to be as effective as a pharmaceutical tricyclic antidepressant (TCA) in supporting healthy mood.⁴
• Inflammation up-regulates enzymes and pathways involved in mood. An animal study has shown that activation of inflammatory pathways via nuclear factor – κB (NF-κB) and mitogen activated protein kinases (MAPk) has been implicated in the pathophysiology of low mood. NF-κB leads to increased release of interferon-gamma and other cytokines, which eventually lead to dysregulation of the HPA axis, impaired metabolism of monoamine neurotransmitters (i.e. serotonin, dopamine and noradrenaline) and reduced neuronal plasticity.⁷
• Curcumin and saffron address multiple contributors to low mood. Curcumin has shown, in animal studies, to increase neurogenesis, potentially via modulation of the hypothalamic-pituitary-adrenal (HPA) axis and by increasing brain derived neurotrophic factor (BDNF) production in the brain⁷. It also:
  • Is a potent antioxidant;
  • Modulates inflammation;
  • Provides significant neuroprotection;
  • Influences monoamine transmission through its effect on serotonergic and dopaminergic activity.¹
• Saffron is suggested, in animal studies, to support healthy mood by:
  • Maximising natural levels of monoamines in the brain;
  • Reducing glutamate activity in the brain via N-methyl-D-aspartate (NMDA) receptor antagonism;
  • Enhancing neurogenesis via improved BDNF signalling.⁸